Research Articles
Standardizing Immunology: Protocols and Quality Control for Reproducible Data in Research and Drug Development
Reproducibility in immunological data is fundamental for robust scientific discovery and successful translational research.
Computational Frontiers in Single-Cell Immune Repertoire Analysis: From Data to Clinical Insights
Single-cell immune repertoire analysis has transformed our understanding of adaptive immunity by enabling high-resolution profiling of T-cell and B-cell receptor sequences at the individual cell level.
Deep Learning in Immunotherapy: Predicting Antibody Affinity and TCR Binding for Accelerated Drug Discovery
This article explores the transformative role of deep learning (DL) in predicting antibody-antigen affinity and T-cell receptor (TCR)-peptide-MHC binding, two critical interactions in immunotherapy development.
Microfluidic Platforms for Modeling Vascular Inflammation: A Comprehensive Guide to TEER Measurements and Applications
This article provides researchers, scientists, and drug development professionals with a comprehensive overview of microfluidic platforms for modeling vascular inflammation, with a focus on Transendothelial Electrical Resistance (TEER) as a...
Generating Functionally Active Adipose Tissue-Resident Macrophages Using 3D Culture Systems: A Protocol and Review
This article provides a comprehensive resource for researchers and drug development professionals on the generation and application of functionally active adipose tissue-resident macrophages using advanced 3D culture systems.
A Comprehensive Guide to MiXCR: Mastering Immune Repertoire Analysis for Research and Drug Development
This article provides a comprehensive guide to MiXCR, a powerful computational tool for immune repertoire analysis.
In Silico Mechanistic Modeling of the Immune Response to Burn Injuries: From Cellular Dynamics to Clinical Translation
This article provides a comprehensive overview of in silico mechanistic modeling approaches for deciphering the complex immune response following burn injuries.
Bayesian Optimization in Antibody Design: A New Frontier for Accelerated Therapeutic Discovery
This article explores the transformative role of Bayesian optimization (BO) in computational antibody design, a field critical for developing new biologics.
Multi-Organ-on-a-Chip Systems: A New Paradigm for Immunotoxicity Assessment in Drug Development
This article explores the transformative role of multi-organ-on-a-chip (MOC) systems in advancing immunotoxicity studies.
Decoding Thymic Involution: A Single-Cell RNA Sequencing Atlas of Aging Dynamics
This comprehensive review synthesizes recent advances in single-cell RNA sequencing (scRNA-seq) that are revolutionizing our understanding of thymus aging.