Research Articles
Decoding TCR-pMHC Interactions: From Fundamental Principles to Therapeutic Applications in Adaptive Immunity
This article provides a comprehensive examination of T-cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions, the cornerstone of adaptive cellular immunity.
Decoding Tissue Immunity: Insights from Human Postmortem Studies
This article synthesizes recent advances in our understanding of tissue-specific immune responses, with a particular focus on insights gained from human postmortem studies.
Decoding Immune Variation: How Genetics and Environment Shape Human Health and Disease Treatment
This article provides a comprehensive analysis for researchers and drug development professionals on the complex interplay between genetic susceptibility and environmental factors in shaping inter-individual immune variation.
Immune System Heterogeneity in Autoimmune Disease: From Molecular Mechanisms to Precision Therapies
Autoimmune diseases, affecting 7-10% of the global population, are characterized by profound immune system heterogeneity that dictates disease susceptibility, clinical presentation, and treatment response.
Decoding B-Cell Evolution: A Guide to Phylogenetic Analysis for Therapeutic Discovery
This article provides a comprehensive resource for researchers and drug development professionals on the application of phylogenetic analysis to B-cell receptor (BCR) repertoires.
Multi-Scale Modeling of Lymphocyte Development, Interaction, and Diversity: From Computational Foundations to Clinical Translation
This article provides a comprehensive overview of multi-scale computational modeling approaches for elucidating the complexity of lymphocyte development, interaction, and diversity.
Decoding Immune Defense: A Network Analysis Guide to Immune Repertoire Architecture
This article provides a comprehensive guide for researchers and drug development professionals on applying network analysis to dissect the complex architecture of adaptive immune repertoires.
Spatial Proteomics at Single-Cell Resolution: Unlocking Cellular Heterogeneity with DNA-Tagged Antibodies and Sequencing
This article explores the transformative field of spatial proteomics using DNA-tagged antibodies and sequencing, a technology that maps the precise location and interactions of proteins within individual cells.
Decoding Human CD8+ T Cell Heterogeneity: A Comprehensive Guide to Single-Cell RNA Sequencing Atlases and Their Applications in Biomedical Research
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of CD8+ T cell biology, revealing an unprecedented degree of heterogeneity in health, aging, and disease.
El mal de Chagas: A Silent Pandemic Where Biology and Poverty Intersect
Exploring Chagas disease as a silent pandemic requiring collaboration between biological and social sciences for effective control of this disease of poverty.