Research Articles
AI in Immunology: Benchmarking Protein Structure Prediction Models for Antibodies, TCRs, and Vaccine Design
This article provides a comparative analysis of AI-driven protein structure prediction models, with a specialized focus on immunology applications.
Validating Multi-Organ-on-a-Chip Systems to Recapitulate Human Immunity for Next-Generation Therapeutic Development
This article explores the groundbreaking role of validated multi-organ-on-a-chip (MOC) systems in revolutionizing preclinical research by accurately modeling human immune responses.
Beyond the Dish: How 3D Culture is Reshaping Our Understanding of Macrophage Biology and Drug Discovery
This article provides a comprehensive comparison between traditional 2D and advanced 3D culture systems for macrophages, crucial innate immune cells.
A Comprehensive Guide to In Vitro Immunogenicity Assessment for Peptide-Based Vaccines
This article provides a systematic framework for researchers and drug development professionals to evaluate the immunogenicity of peptide-based vaccines using in vitro assays.
Comparative Analysis of Machine Learning Methods in Computational Immunology: From Algorithms to Clinical Translation
This article provides a comprehensive comparative analysis of machine learning (ML) methods revolutionizing computational immunology.
Benchmarking Single-Cell Annotation Methods for T Cell Subsets: A Comprehensive Guide for Immunologists and Bioinformaticians
This comprehensive review examines the current landscape of computational methods for annotating T cell subsets in single-cell RNA sequencing data.
Divergent Pathogenicity of SARS-CoV-2 Delta and Omicron Variants: Insights from 3D Respiratory Models
This article synthesizes current research comparing the pathogenicity of SARS-CoV-2 Delta and Omicron variants, with a specific focus on findings from advanced 3D respiratory models.
Antibody Validation for Flow Cytometry and Western Blot: A Guide to Reproducible Research
This article provides a comprehensive guide for researchers and drug development professionals on validating antibodies for flow cytometry and western blot applications.
Beyond Animal Models: How New Approach Methods (NAMs) Are Revolutionizing Immunology Research and Drug Development
This article provides a comprehensive overview of the paradigm shift towards New Approach Methods (NAMs) in immunology.
Standardizing High-Dimensional Cytometry Data: A Comprehensive Guide from Experimental Design to Clinical Validation
High-dimensional cytometry has revolutionized single-cell analysis, yet its full potential in biomedical research and drug development is hampered by standardization challenges.