Research Articles
Scalable Multi-Omics Integration: A Deep Dive into MOFA+ and Stochastic Variational Inference for Large-Scale Biomedical Datasets
This article provides a comprehensive guide to scaling Multi-Omics Factor Analysis (MOFA+) for large datasets using variational inference.
MOFA+: The Ultimate Guide to Multi-Omics Single-Cell Data Integration for Biomedical Research
This comprehensive guide explores MOFA+, a powerful statistical framework for integrating multi-omics single-cell data.
Decoding Sepsis Complexity: A Guide to MOFA+ for Immune Cell Heterogeneity Analysis in Drug Development
This article provides a comprehensive guide for biomedical researchers and drug development professionals on applying Multi-Omics Factor Analysis plus (MOFA+) to dissect immune cell heterogeneity in sepsis.
MOFA+, Seurat, LIGER, and GLUE: Benchmarking Integration Power for Single-Cell Multi-Omics Analysis in 2024
This article provides a comprehensive, up-to-date performance comparison and practical guide for four leading single-cell multi-omics integration tools: MOFA+, Seurat (v5), LIGER, and GLUE.
From Lab to Clinic: A Practical Guide to MLOps for Clinical Immunology and Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on implementing Machine Learning Operations (MLOps) in clinical immunology.
Overcoming MHC Restriction: The Critical Challenge in Designing Effective Peptide-Based Vaccines
This article provides a comprehensive analysis of Major Histocompatibility Complex (MHC) restriction as a central challenge in peptide-based vaccine development.
Advancing Metabolic Disease Research: A Complete Guide to Differentiating Adipose Tissue Macrophages with M-CSF in 3D Culture
This comprehensive guide details the methodology and application of using Macrophage Colony-Stimulating Factor (M-CSF) to differentiate and maintain adipose tissue macrophages (ATMs) within three-dimensional (3D) culture systems.
Levenshtein vs. Hamming Distance for Immune Sequence Analysis: A Guide for Precision Immunology Research
This article provides a comprehensive guide for immunology researchers and drug development scientists on applying Levenshtein (edit) and Hamming distance metrics to immune receptor sequences (e.g., TCRs, BCRs).
Langerhans Cells in 3D Skin Models: Function, Culture, and Applications in Immunology Research
This article provides a comprehensive guide for researchers and pharmaceutical developers on the critical role and study of Langerhans cells (LCs) within in vitro skin models.
Mastering LISI Score Interpretation: A Complete Guide to Batch Effect Removal for Single-Cell Data Analysis
This comprehensive guide addresses four critical needs for researchers analyzing single-cell data.