Research Articles
In Silico Mechanistic Modeling of the Immune Response to Burn Injuries: From Cellular Dynamics to Clinical Translation
This article provides a comprehensive overview of in silico mechanistic modeling approaches for deciphering the complex immune response following burn injuries.
Bayesian Optimization in Antibody Design: A New Frontier for Accelerated Therapeutic Discovery
This article explores the transformative role of Bayesian optimization (BO) in computational antibody design, a field critical for developing new biologics.
Multi-Organ-on-a-Chip Systems: A New Paradigm for Immunotoxicity Assessment in Drug Development
This article explores the transformative role of multi-organ-on-a-chip (MOC) systems in advancing immunotoxicity studies.
Decoding Thymic Involution: A Single-Cell RNA Sequencing Atlas of Aging Dynamics
This comprehensive review synthesizes recent advances in single-cell RNA sequencing (scRNA-seq) that are revolutionizing our understanding of thymus aging.
Decoding TCR-pMHC Interactions: From Fundamental Principles to Therapeutic Applications in Adaptive Immunity
This article provides a comprehensive examination of T-cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions, the cornerstone of adaptive cellular immunity.
Decoding Immune Variation: How Genetics and Environment Shape Human Health and Disease Treatment
This article provides a comprehensive analysis for researchers and drug development professionals on the complex interplay between genetic susceptibility and environmental factors in shaping inter-individual immune variation.
Decoding Tissue Immunity: Insights from Human Postmortem Studies
This article synthesizes recent advances in our understanding of tissue-specific immune responses, with a particular focus on insights gained from human postmortem studies.
Immune System Heterogeneity in Autoimmune Disease: From Molecular Mechanisms to Precision Therapies
Autoimmune diseases, affecting 7-10% of the global population, are characterized by profound immune system heterogeneity that dictates disease susceptibility, clinical presentation, and treatment response.
Decoding B-Cell Evolution: A Guide to Phylogenetic Analysis for Therapeutic Discovery
This article provides a comprehensive resource for researchers and drug development professionals on the application of phylogenetic analysis to B-cell receptor (BCR) repertoires.
Multi-Scale Modeling of Lymphocyte Development, Interaction, and Diversity: From Computational Foundations to Clinical Translation
This article provides a comprehensive overview of multi-scale computational modeling approaches for elucidating the complexity of lymphocyte development, interaction, and diversity.